Publications

Have a look at all publications related to the GRK 2046.
For your convenience, we have divided this section into scientific publications and various public outreach

Scientific publications

Publications in 2024
(Due date: August 15, 2024)

Midha A, Oser L, Schlosser-Brandenburg J, Laubschat A, Mugo RM, Musimbi ZD, Höfler P, Kundik A, Hayani R, Adjah J, Groenhagen S, Tieke M, Elizalde-Velázquez LE, Kühl AA, Klopfleisch R, Tedin K, Rausch S, Hartmann S. (2024).
Concurrent Ascaris infection modulates host immunity resulting in impaired control of Salmonella infection in pigs.
mSphere Aug 14:e0047824. doi: 10.1128/msphere.00478-24.

Fraser M, Curtis B, Phillips P, Yates PA, Lam KS, Netzel O, van Dooren GG, Ingmundson A, Matuschewski K, McLeod MD, Maier AG. (2024).
Harnessing cholesterol uptake of malaria parasites for therapeutic applications.
EMBO Mol Med 16:1515-1532. doi: 10.1038/s44321-024-00087-1.

Diekmann I, Blazejak K, Krücken J, Strube C, von Samson-Himmelstjerna G. (2024).
Comparison of morphological and molecular Strongylus spp. identification in equine larval cultures and first report of a patent Strongylus asini infection in a horse.
Equine Vet J doi: 10.1111/evj.14134.

Jarquín-Díaz VH, Ferreira SCM, Balard A, Ďureje Ľ, Macholán M, Piálek J, Bengtsson-Palme J, Kramer-Schadt S, Forslund-Startceva SK, Heitlinger E. (2024).
Aberrant microbiomes are associated with increased antibiotic resistance gene load in hybrid mice.
ISME Commun 4:ycae053. doi: 10.1093/ismeco/ycae053.

Scholz C, Jarquín-Díaz VH, Planillo A, Radchuk V, Scherer C, Schulze C, Ortmann S, Kramer-Schadt S, Heitlinger E. (2024).
Host weight, seasonality and anthropogenic factors contribute to parasite community differences between urban and rural foxes.
Sci Total Environ 936:173355. doi: 10.1016/j.scitotenv.2024.173355.

Elizalde-Velázquez LE, Schlosser-Brandenburg J, Laubschat A, Oser L, Kundik A, Adjah J, Groenhagen S, Kühl AA, Rausch S, Hartmann S. (2024).
Th2-biased immune responses to body migrating Ascaris larvae in primary infection are associated with pathology but not protection.
Sci Rep 14:14919. doi: 10.1038/s41598-024-65281-0.

Mugo RM, Oser L, Midha A, Adjah J, Kundik A, Laubschat A, Höfler P, Musimbi ZD, Hayani R, Schlosser-Brandenburg J, Hartmann S, Rausch S. (2024).
Acute Ascaris infection impairs effector functions of natural killer cells in single and Salmonella co-infected pigs.
Sci Rep 14:14586. doi: 10.1038/s41598-024-64497-4.

Mugo RM, Rausch S, Musimbi ZD, Strube C, Raulf MK, Landt O, Gichuki PM, Ebner F, Mwacharo J, Odiere MR, Ndungu FM, Njomo DW, Hartmann S. (2024).
Evaluation of copromicroscopy, multiplex-qPCR and antibody serology for mon-itoring of human ascariasis in endemic settings.
PLOS Negl Trop Dis 18:e0012279. doi: 10.1371/journal.pntd.0012279.

Oser L, Midha A, Schlosser-Brandenburg J, Rausch S, Mugo RM, Kundik A, Elizalde-Velázquez LE, Adjah J, Musimbi ZD, Klopfleisch R, Helm CS, von Samson-Himmelstjerna G, Hartmann S, Ebner F. (2024).
Ascaris suum infection in juvenile pigs elicits a local Th2 response in a setting of ongoing Th1 expansion.
Front Immunol 15:1396446. doi: 10.3389/fimmu.2024.

Katelas DA, Cruz-Miron R, Arroyo-Olarte RD, Brouwers JF, Srivastav RK, Gupta N. (2024).
Phosphatidylserine Synthase in the Endoplasmic Reticulum of Toxoplasma is Essential for its Lytic Cycle in Human Cells.
J Lipid Res 2024 65:100535. doi: 10.1016/j.jlr.2024.100535.

Maus D, Curtis B, Warschkau D, Betancourt ED, Seeber F, Blume M. (2024).
Generation of Mature Toxoplasma gondii Bradyzoites in Human Immortalized Myogenic KD3 Cells.
Bio Protoc 14(1):e4916. doi: 10.21769/BioProtoc.4916.

Publications in 2023

Arranz-Solís D*, Warschkau D*, Fabian BT, Seeber F, Saeij JPJ. (2023).
Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses.
mBio 14:e0286822. doi: 10.1128/mbio.02868-22. *equal contribution

Elizalde-Velázquez LE, Yordanova IA, Liublin W, Adjah J, Leben R, Rausch S, Niesner R, Hartmann S. (2023).
Th2 and metabolic responses to nematodes are independent of prolonged host microbiota abrogation.

Ferreira SCM, Jarquín-Díaz VH, Heitlinger E. (2023).
Amplicon sequencing allows differential quantification of closely related parasite species: an example from rodent Coccidia (Eimeria).
Parasit Vectors 16:204. doi: 10.1186/s13071-023-05800-6.

Goerdeler F, Reuber EE, Lühle J, Leichnitz S, Freitag A, Nedielkov R, Groza R, Ewers H, Möller HM, Seeberger PH, Moscovitz O. (2023).
Thiol-Mediated Uptake of a Cysteine-Containing Nanobody for Anticancer Drug Delivery.
ACS Cent Sci 9:1111-8. doi: 10.1021/acscentsci.3c00177.

Khilji SK, Op 't Hoog C, Warschkau D, Lühle J, Goerdeler F, Freitag A, Seeberger PH, Moscovitz O. (2023).
Smaller size packs a stronger punch - Recent advances in small antibody fragments targeting tumour-associated carbohydrate antigens.
Theranostics 13:3041-3063. doi: 10.7150/thno.80901.

Klotz C, Schmid MW, Winter K, Ignatius R, Weisz F, Saghaug CS, Langeland N, Dawson S, Lalle M, Hanevik K, Cacciò SM, Aebischer T. (2023).
Highly contiguous genomes of human clinical isolates of Giardia duodenalis reveal assemblage- and sub-assemblage-specific presence-absence variation in protein-coding genes.
Microb Genom 9:mgen000963. doi: 10.1099/mgen.0.000963.

Kundik A, Musimbi ZD, Krücken J, Hildebrandt T, Kornilov O, Hartmann S, Ebner F. (2023).
Quantifying metabolic activity of Ascaris suum L3 using resazurin reduction.
Parasit Vectors 16:243. doi: 10.1186/s13071-023-05871-5.

Liublin W, Rausch S, Leben R, Liebeskind J, Hauser AE, Hartmann S, Niesner RA. (2023).
NAD(P)H Fluorescence Lifetime Imaging for the Metabolic Analysis of the Murine Intestine and Parasites During Nematode Infection.
J Vis Exp Sep 1;(199). doi: 10.3791/64982.

Militzer N, Pinecki Socias S, Nijhof AM. (2023).
Changes in the Ixodes ricinus microbiome associated with artificial tick feeding.
Front Microbiol 13:1050063. doi: 10.3389/fmicb.2022.1050063.

Schlosser-Brandenburg J, Midha A, Mugo RM, Ndombi EM, Gachara G, Njomo D, Rausch S, Hartmann S. (2023).
Infection with soil-transmitted helminths and their impact on coinfections.
Front Parasitol published May 24. doi: 10.3389/fpara.2023.1197956. Review (https://www.frontiersin.org/articles/10.3389/fpara.2023.1197956/full)

Schüler V, Liu YC, Gisder S, Horchler L, Groth D, Genersch E. (2023).
Significant, but not biologically relevant: Nosema ceranae infections and winter losses of honey bee colonies.
Commun Biol 6:229. doi: 10.1038/s42003-023-04587-7.

van Loon W, Oliveira R, Bergmann C, Habarugira F, Tacoli C, Jäger J, Savelsberg D, Mbarushimana D, Ndoli JM, Sendegeya A, Bayingana C, Mockenhaupt FP. (2023).
Plasmodium vivax Malaria in Duffy-Positive Patients in Rwanda.
Am J Trop Med Hyg 109:621-3. doi: 10.4269/ajtmh.23-0143.

Warschkau D, Seeber F. (2023).
Advances towards the complete in vitro life cycle of Toxoplasma gondii.
Fac Rev 12:1. doi: 10.12703/r/12-1.

Yordanova IA, Elizalde-Velázquez LE, Hartmann S. (2023).
Immunization with excretory-secretory molecules of intestinal nematodes induces antigen-specific protective memory Th2 cell responses.
Eur J Immunol 53:e2250237. doi: 10.1002/eji.202250237.

Publications in 2022

Ben Ami Pilo H*, Khilji SK*, Lühle J*, Biskup K, Gal BL, Rosenhek Goldian I, Alfandari D, Revach OY, Kiper E, Morandi MI, Rotlopf R, Porat Z, Blanchard V, Seeberger PH, Regev-Rudzki N, Moscovitz O. (2022).
Sialylated N-glycans mediate monocyte uptake of extracellular vesicles secreted from Plasmodium falciparum-infected red blood cells.
J Extracellular Biol 1:e33. doi: 10.1002/jex2.33. *equal contribution

Gicquel M, East ML, Hofer H, Benhaiem S. (2022).
Early-life adversity predicts performance and fitness in a wild social carnivore.
J Anim Ecol 91:2074-2086. doi: 10.1111/1365-2656.13785.

Hamid B, Ebner F, Bechtold L, Kundik A, Rausch S, Hartmann S. (2022).
Ascaris suum excretory/secretory products differentially modulate porcine dendritic cell subsets.
Front Immunol 13:1012717. doi: 10.3389/fimmu.2022.1012717.

Holthaus D*, Kraft MR*, Krug SM, Wolf S, Müller A, Delgado Betancourt E, Schorr M, Holland G, Knauf F, Schulzke JD, Aebischer T^§, Klotz C^§. (2021).
Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis.
Gastroenterology 162:844-58. doi: 10.1053/j.gastro.2021.11.022. *^/§equal contribution

Jakobs N,Yilmaz E, Krücken J. (2022).
Transgenic Expression of Haemonchus contortus Cytochrome P450 Hco-cyp-13A11 Decreases Susceptibility to Particular but Not All Macrocyclic Lactones in the Model Organism Caenorhabditis elegans.
Int J Mol Sci 23:9155 doi: 10.3390/ijms23169155.

Jarquín-Díaz VH, Balard A, Ferreira SCM, Mittné V, Murata JM, Heitlinger E. (2022).
DNA‑based quantification and counting of transmission stages provides different but complementary parasite load estimates: an example from rodent coccidia (Eimeria).
Parasit Vectors 15:45. doi: 10.1186/s13071-021-05119-0.

Kapse B, Zhang H, Affinass N, Ebner F, Hartmann S, Rausch S. (2022).
Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection.
Mucosal Immunol Jun 11. doi: 10.1038/s41385-022-00519-6.

Khilji SK*, Goerdeler F*, Frensemeier K, Warschkau D, Lühle J, Fandi Z, Schirmeister F, Chen ZA, Turak O, Mallagaray A, Boerno S, Timmermann B, Rappsilber J, Seeberger PH, Moscovitz O. (2022).
Generation of glycan-specific nanobodies.
Cell Chem Biol Jun 6:S2451-9456(22)00199-4. doi: 10.1016/j.chembiol.2022.05.007.*equal contribution

Liublin W, Rausch S, Leben R, Lindquist RL, Fiedler A, Liebeskind J, Beckers IE, Hauser AE, Hartmann S, Niesner RA. (2022).
NAD(P)H fluorescence lifetime imaging of live intestinal nematodes reveals metabolic crosstalk between parasite and host.
Sci Rep 12:7264. doi: 10.1038/s41598-022-10705-y.

van Loon W, Oliveira R, Bergmann C, Habarugira F, Ndoli J, Sendegeya A, Bayingana C, Mockenhaupt FP. (2022).
In Vitro Confirmation of Artemisinin Resistance in Plasmodium falciparum from Patient Isolates, Southern Rwanda, 2019.
Emerg Infect Dis 28:852-5. doi: 10.3201/eid2804.212269.

Warschkau D, Delgado Betancourt E, Holthaus D, Müller A, Kliem G, Krug SM, Schulzke JD, Aebischer T, Klotz C, Seeber F. (2022).
From 3D to 2D: Harmonization of Protocols for Two-dimensional Cultures on Cell Culture Inserts of Intestinal Organoids from Various Species.
Bio Protoc 12:e4295. doi: 10.21769/BioProtoc.4295.

Weiß F, Holthaus D, Kraft M, Klotz C, Schneemann M, Schulzke JD, Krug SM. (2022).
Human duodenal organoid-derived monolayers serve as a suitable barrier model for duodenal tissue.
Ann N Y Acad Sci 1515:155-67. doi: 10.1111/nyas.148045.

Zhang Hongwei, Bednář L, Heitlinger E, Hartmann S, Rausch S. (2022).
Whip- and pinworm infections elicit contrasting effector and distinct regulatory responses in wild house mice.
Int J Parasitol S0020-7519(22)00080-7. doi: 10.1016/j.ijpara.2022.03.006.

Publications in 2021

Bergmann C, van Loon W, Habarugira F, Tacoli C, Jäger JC, Savelsberg D, Nshimiyimana F, Rwamugema E, Mbarushimana D, Ndoli J, Sendegeya A, Bayingana C, Mockenhaupt FP. (2021).
Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda.
Emerg Infect Dis 27:294–6. doi: 10.3201/eid2701.203527.

Fabian BT, Lepenies B, Schares G, Dubey JP, Spano F, Seeber F. (2021).
Expanding the Known Repertoire of C-Type Lectin Receptors Binding to Toxoplasma gondii Oocysts Using a Modified High-Resolution Immunofluorescence Assay.
mSphere 6:e01341-20. doi: 10.3390/ph14020153.

Ferreira SCM, Veiga MM, Hofer H, East ML, Czirják GÁ. (2021).
Noninvasively measured immune responses reflect current parasite infections in a wild carnivore and are linked to longevity.
Ecol Evol 11:7685-99. doi: 10.1002/ece3.7602.

Gerhard AP, Krücken J, Neveu C. Charvet CL, Harmache A, von Samson-Himmelstjerna G. (2021).
Pharyngeal Pumping and Tissue-Specific Transgenic P-Glycoprotein Expression Influence Macrocyclic Lactone Susceptibility in Caenorhabditis elegans.
Pharmaceuticals (Basel) 14:153. doi: 10.3390/ph14020153.

Goerdeler F, Seeberger PH, Moscovitz O. (2021).
Unveiling the Sugary Secrets of Plasmodium Parasites.
Front Microbiol 12:712538. doi: 10.3389/fmicb.2021.712538.

Hamid B, Schlosser-Brandenburg J, Bechtold L, Ebner F, Rausch S, Hartmann S. (2021).
Early Immune Initiation by Porcine Cells following Toxoplasma gondii Infection versus TLR Ligation.
Microorganisms 9:1828. doi: 10.3390/microorganisms9091828.

Holthaus D, Delgado-Betancourt E, Aebischer T, Seeber F, Klotz C. (2021).
Harmonization of Protocols for Multi-Species Organoid Platforms to Study the Intestinal Biology of Toxoplasma gondii and Other Protozoan Infections.
Front Cell Infect Microbiol 10:610368. doi: 10.3389/fcimb.2020.610368.

Hon C, Friesen J, Ingmundson A, Scheppan D, Hafalla JCR, Müller K, Matuschewski K. (2021).
Conservation of S20 as an Ineffective and Disposable IFNγ-Inducing Determinant of Plasmodium Sporozoites Indicates Diversion of Cellular Immunity.
Front Microbiol 12:703804. doi: 10.3389/fmicb.2021.703804.

Kreutzfeld O, Grützke J, Ingmundson A, Müller K, Matuschewski K. (2021).
Absence of PEXEL-Dependent Protein Export in Plasmodium Liver Stages Cannot Be Restored by Gain of the HSP101 Protein Translocon ATPase.
Front Genet 12:742153. doi: 10.3389/fgene.2021.742153.

Krücken J, Czirják GÁ, Ramünke S, Serocki M, Heinricht SK, Melzheimer J, Costa MC, Hofer H, Aschenborn OHK, Barker NA, Capodanno S, Madeira de Carvalho L, von Samson-Himmelstjerna G, East ML, Wachter B. (2021).
Genetic diversity of vector‑borne pathogens in spotted and brown hyenas from Namibia and Tanzania relates to ecological conditions rather than host taxonomy.
Parasit Vectors 14:328. doi: 10.1186/s13071-021-04835-x.

Louro M, Kuzmina TA, Bredtmann CM, Diekmann I, de Carvalho LMM, von Samson-Himmelstjerna G, Krücken J. (2021).
Genetic variability, cryptic species and phylogenetic relationship of six cyathostomin species based on mitochondrial and nuclear sequences.
Sci Rep 11:8245. doi: 10.1038/s41598-021-87500-8.

Merling de Chapa M, Auls S, Kenntner N, Krone O. (2021).
To get sick or not to get sick—Trichomonas infections in two Accipiter species from Germany.
Parasitol Res 120:3555-67. doi: 10.1007/s00436-021-07299-1.

Midha A, Ebner F, Schlosser-Brandenburg J, Rausch S, Hartmann S. (2021).
Trilateral relationship: Ascaris, microbiota, and host cells.
Trends Parasitol 37:251-62. doi: 10.1016/j.pt.2020.09.002.

Midha A,Goyette-Desjardins G, Goerdeler F, Moscovitz O, Seeberger PH, Tedin K, Bertzbach LD, Lepenies B, Hartmann S. (2021).
Lectin-Mediated Bacterial Modulation by the Intestinal Nematode Ascaris suum.
Int J Mol Sci 22:8739. doi: 10.3390/ijms22168739.

Militzer N, Bartel A , Clausen PH, Hoffmann-Köhler P, Nijhof AM. (2021).
Artificial Feeding of All Consecutive Life Stages of Ixodes ricinus.
Vaccines (Basel) 9:385. doi: 10.3390/vaccines9040385.

Schares G, Joeres M, Rachel F, Tuschy M, Czirják GÁ, Maksimov P, Conraths FJ, Wachter B. (2021).
Molecular analysis suggests that Namibian cheetahs (Acinonyx jubatus) are definitive hosts of a so far undescribed Besnoitia species.
Parasit Vectors 14:201. doi: 10.1186/s13071-021-04697-3.

Schlosser-Brandenburg J, Ebner F, Klopfleisch R, Kühl AA, Zentek J, Pieper R, Hartmann S. (2021).
Influence of Nutrition and Maternal Bonding on Postnatal Lung Development in the Newborn Pig.
Front Immunol 12:734153. doi: 10.3389/fimmu.2021.734153.

Siegert K, van Loon W, Gai PP, Rohmann JL, Piccininni M, Näher AF, Boloor A, Shenoy D, Mahabala C, Kulkarni SS, Kumar A, Wedam J, Gai P, Devi R, Jain A, Kurth T, Mockenhaupt FP. (2021).
The Effect of Socioeconomic Factors and Indoor Residual Spraying on Malaria in Mangaluru, India: A Case-Control Study.
Int J Environ Res Public Health 18:11853. doi: 10.3390/ijerph182211853.

van Loon W, Bergmann C, Habarugira F, Tacoli C, Savelsberg D, Oliveira R, Mbarushimana D, Ndoli J, Sendegeya A, Bayingana C, Mockenhaupt FP. (2021).
The Changing pattern of Plasmodium falciparum multi-drug resistance-1 gene polymorphisms in southern Rwanda.
Antimicrob Agents Chemother 65:e0090121. doi: 10.1128/AAC.00901-21.

Yordanova IA, Ebner F, Schulz AR, Steinfelder S, Rosche B, Bolze A, Paul F, Mei HE, Hartmann S. (2021).
The Worm-Specific Immune Response in Multiple Sclerosis Patients Receiving Controlled Trichuris suis Ova Immunotherapy.
Life (Basel) 11:101. doi: 10.3390/life11020101.

Yordanova IA, Lamatsch M, Kühl AA, Hartmann S, Rausch S. (2021)
Eosinophils are dispensable for the regulation of IgA and Th17 responses in Giardia muris infection.
Parasite Immunol 43:e12791. doi: 10.1111/pim.12791

Publications in 2020

Balard A, Jarquín-Díaz VH, Jost J, Martincová I, Ďureje Ľ, Piálek J, Macholán M, Goüy de Bellocq J, Baird SJE, Heitlinger E. (2020).
Intensity of infection with intracellular Eimeria spp. and pinworms is reduced in hybrid mice compared to parental subspecies.
J Evol Biol 33:435-48. doi: 10.1111/jeb.13578.

Balard A, Jarquín-Díaz VH, Jost J, Mittné V, Böhning F, Ďureje Ľ, Piálek J, Heitlinger E. (2020).
Coupling between tolerance and resistance for two related Eimeria parasite species.
Ecol Evol 10:13938-48. doi: 10.1002/ece3.6986.

Diekmann I, Alnassan AA, Globokar M, Pantchev N, Kurzrock L, Hernandez L, Lopez J, Ruano R, Herrero S, von Samson-Himmelstjerna G, Krücken J. (2020).
Canine Dracunculus Nematode Infection, Toledo, Spain.
Emerg Infect Dis 26:1860-3. doi: 10.3201/eid2608.201661.

Ebner F, Morrison E, Bertazzon M, Midha A, Hartmann S, Freund C, Álvaro-Benito M. (2020).
CD4⁺ T_h immunogenicity of the Ascaris spp. secreted products.
NPJ Vaccines 5:25. doi: 10.1038/s41541-020-0171-z.

Fabian BT, Hedar F, Koethe M, Bangoura B, Maksimov P, Conraths FJ, Villena I, Aubert D, Seeber F, Schares G. (2020).
Fluorescent bead-based serological detection of Toxoplasma gondii infection in chickens.
Parasit Vectors 13:388. doi: 10.1186/s13071-020-04244-6.

Gerhard AP, Krücken J, Heitlinger E, Janssen IJ, Basiaga M, Kornaś S, Beier C, Nielsen MK, Davis RE, Wang J, von Samson-Himmelstjerna G. (2020).
The P-glycoprotein repertoire of the equine parasitic nematode Parascaris univalens.
Sci Rep 10:13586. doi: 10.1038/s41598-020-70529-6.

Gisder S, Horchler L, Pieper F, Schüler V, Šima P, Genersch E. (2020).
Rapid Gastrointestinal Passage May Protect Bombus terrestris from Becoming a True Host for Nosema ceranae
Appl Environ Microbiol 86:e00629-20. doi: 10.1128/AEM.00629-20.

Hon C, Matuschewski K. (2020).
Malaria According to GARP: A New Trail towards Anti-disease Vaccination.
Trends Parasitol 36:653-5. doi: 10.1016/j.pt.2020.05.012.

Jarquín-Díaz VH, Balard A, Mácova A, Jost J, Roth von Szepesbéla T, Berktold K, Tank S, Kvičerová J, Heitlinger E. (2020).
Generalist Eimeria species in rodents: Multilocus analyses indicate inadequate resolution of established markers.
Ecol Evol 10:1378-89. doi: 10.1002/ece3.5992.

Merling de Chapa M, Courtiol A, Engler M, Giese L, Rutz C, Lakermann M, Müskens G, van der Horst Y, Zollinger R, Wirth H, Kenntner N, Krüger O, Chakarov N, Müller AK, Looft V, Grünkorn T, Hallau A, Altenkamp R, Krone O. (2020).
Phantom of the forest or successful citizen? Analysing how Northern Goshawks (Accipiter gentilis) cope with the urban environment.
R Soc Open Sci 7:201356. doi: 10.1098/rsos.201356.

Prüter H, Franz M, Twietmeyer S, Böhm N, Middendorff G, Portas R, Melzheimer J, Kolberg H, von Samson‑Himmelstjerna G, Greenwood AD, Lüschow D, Mühldorfer K, Czirják GÁ. (2020).
Increased immune marker variance in a population of invasive birds.
Sci Rep 10:21764. doi: 10.1038/s41598-020-78427-7.

Seltmann A, Schares G, Aschenborn OHK, Heinrich SK, Thalwitzer S, Wachter B*, Czirják GÁ* (2020).
Species-specific differences in Toxoplasma gondii, Neospora caninum and Besnoitia besnoiti seroprevalence in Namibian wildlife.
Parasit Vectors 13:7. doi: 10.1186/s13071-019-3871-3. *equal contribution

Varela-Aramburu S, Ghosh C, Goerdeler F, Priegue P, Moscovitz O, Seeberger PH (2020).
Targeting and Inhibiting Plasmodium falciparum Using Ultra-small Gold Nanoparticles.
ACS Appl Mater Interfaces 12:43380–7. doi: 10.1021/acsami.0c09075.

van Loon W, Gai PP, Kulkarni SS, Rasalkar R, Siegert K, Wedam J, Boloor A, Baliga S, Kumar A, Jain A, Mahabala C, Shenoy D, Devi R, Gai P, Mockenhaupt FP (2020).
MiRNA-146a Polymorphism Was Not Associated with Malaria in Southern India.
Am J Trop Med Hyg 102:1072-4. doi: 10.4269/ajtmh.19-0845.

Publications in 2019

Ahmed N, Heitlinger E, Affinass N, Kühl AA, Xenophontos N, Jarquin VH, Jost J, Steinfelder S, Hartmann S. (2019).
A novel non-invasive method to detect RELM beta transcript in gut barrier related changes during a gastrointestinal nematode infection.
Front Immunol 10:445. doi: 10.3389/fimmu.2019.00445.

Bredtmann CM, Krücken J, Kuzmina T, Louro M, Madeira de Carvalho LM, von Samson-Himmelstjerna G. (2019)
Nuclear and mitochondrial marker sequences reveal close relationship between Coronocyclus coronatus and a potential Cylicostephanus calicatus cryptic species complex.
Infect Genet Evol 9:103956. doi: 10.1016/j.meegid.2019.103956.

Bredtmann CM, Krücken J, Murugaiyan J, Balard A, Hofer H, Kuzmina TA, von Samson-Himmelstjerna G. (2019).
Concurrent Proteomic Fingerprinting and Molecular Analysis Of Cyathostomins.
Proteomics 20:e1800290. doi: 10.1002/pmic.201800290.

Costantini D, Czirják GÀ, Melzheimer J, Menges V, Wachter B. (2019).
Sex and species differences of stress markers in sympatric cheetahs and leopards in Namibia.
Comp Biochem Physiol A Mol Integr Physiol 227:8-13. doi: 10.1016/j.cbpa.2018.09.002.

Delgado Betancourt E, Hamid B, Fabian BT, Klotz C, Hartmann S, Seeber F. (2019).
From Entry to Early Dissemination-Toxoplasma gondii's Initial Encounter With Its Host.
Front Cell Infect Microbiol 9:46. doi: 10.3389/fcimb.2019.00046.

Ferreira SCM, Hofer H, Madeira de Carvalho L, East ML. (2019).
Parasite infections in a social carnivore: Evidence of their fitness consequences and factors modulating infection load.
Ecol Evol 9:8783-99. doi: 10.1002/ece3.5431.

French T, Düsedau HP, Steffen J, Biswas A, Ahmed N, Hartmann S, Schüler T, Schott BH, Dunay IR. (2019).
Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner.
J Neuroinflammation 16:159. doi: 10.1186/s12974-019-1539-8.

Gai PP, van Loon W, Siegert K, Wedam J, Kulkarni SS, Rasalkar R, Boloor A, Kumar A, Jain A, Mahabala C, Baliga S, Devi R, Shenoy D, Gai P Mockenhaupt FP. (2019).
Duffy antigen receptor for chemokines gene polymorphisms and malaria in Mangaluru, India (2019).
Malar J 18:328. doi: 10.1186/s12936-019-2966-9.

Jarquín-Díaz VH, Balard A, Jost J, Kraft J, Dikmen MN, Kvičerová J, Heitlinger E. (2019).
Detection and quantification of house mouse Eimeria at the species level – challenges and solutions for the assessment of Coccidia in wildlife.
Int J Parasitol Parasites Wildl 10:29-40. doi: 10.1016/j.ijppaw.2019.07.004

Seltmann A, Webster F, Martins Ferreira SC, Czirják GÁ*, Wachter B*. (2019).
Age-specific gastrointestinal parasite shedding in free-ranging cheetahs (Acinonyx jubatus) on Namibian farmland
Parasitol Res 118:851-9. doi: 10.1007/s00436-018-6190-2. *equal contribution.

Tacoli C, Gai PP, Siegert K, Wedam J, Kulkarni SS, Rasalkar R, Boloor A, Jain A, Mahabala C, Baliga S, Shenoy D, Gai P, Devi R, Mockenhaupt FP. (2019).
Characterization of Plasmodium vivax pvmdr1 polymorphisms in isolates from Mangaluru, India.
Am J Trop Med Hyg 101:416-7. doi: 10.4269/ajtmh.19-0224.

van Loon W, Gai PP, Hamann L, Bedu-Addo G, Mockenhaupt FP. (2019).
MiRNA-146a polymorphism increases the odds of malaria in pregnancy.
Malar J 18:7. doi: 10.1186/s12936-019-2643-z.

Yilmaz E, Gerst B, McKay-Demeler J, Krücken J. (2019).
Minimal modulation of macrocyclic lactone susceptibility in Caenorhabditis elegans following inhibition of cytochrome P450 monooxygenase activity.
Exp Parasitol 200:61-6. doi: 10.1016/j.exppara.2019.03.017.

Yilmaz E, Wongkamchai S, Ramünke S, Koutsovoulos GD, Blaxter M, Popper S, Schaper R, von Samson-Himmelstjerna G, Krücken J. (2019).
High genetic diversity in the Dirofilaria repens species complex revealed by complete and partial mitochondrial genomes of canine and feline microfilaria samples from Narathiwat, Thailand.
Transbound Emerg Dis 66: 389-99. doi: 10.1111/tbed.13033.

Yordanova IA, Cortés A, Klotz C, Kühl AA, Heimesaat M.M, Cantacessi C, Hartmann S, Rausch S. (2019).
RORγt⁺ Treg to Th17 ratios correlate with susceptibility to Giardia infection.
Sci Rep 9:20328. doi: 10.1038/s41598-019-56416-9.

Publications in 2018

Affinass N, Zhang H, Löhning M, Hartmann S, Rausch S. (2018).
Manipulation of the balance between Th2 and Th2/1 hybrid cells effects parasite nematode fitness.
Eur J Immunol 48:1958-64. doi: 10.1002/eji.201847639.

Aebischer T, Matuschewski K, Hartmann S. (2018).
Editorial: Parasite Infections: From Experimental Models to Natural Systems.
Front Cell Infect Microbiol 8: 1–3. doi: 10.3389/fcimb.2018.00012.

Arroyo-Olarte RD, Thurow L, Kozjak-Pavlovic V, Gupta N. (2018).
Illuminating pathogen-host intimacy through optogenetics.
PLoS Pathogens 14: e1007046. doi: 10.1371/journal.ppat.1007046.

Blume M, Seeber F. (2018).
Metabolic interactions between Toxoplasma gondii and its host.
F1000Res 7:F1000 Faculty Rev-1719. doi: 10.12688/f1000research.16021.1.

Ebner F, Kuhring M, RadonićA, Midha A, Renard B, Hartmann S. (2018).
Silent witness: Dual-species transcriptomics reveals epithelial immunological quiescence to helminth larval encounter and fostered larval development.
Front Immunol 9:1968. doi: 10.3389/fimmu.2018.01868.

Erler H, Ren B, Gupta N*, Beitz E*. (2018).
The intracellular parasite Toxoplasma gondii harbors three druggable FNT-type formate and L-lactate transporters in the plasma membrane.
J Biol Chem 293:17622-30. doi: 10.1074/jbc.RA118.0038016, *co-communication authors.

Esu E, Tacoli C, Gai P, Berens-Riha N, Pritsch M, Loescher T, Meremikwu M. (2018).
Prevalence of the Pfdhfr and Pfdhps mutations among asymptomatic pregnant women in Southeast Nigeria.
Parasitol Res 117:801-7. doi: 10.1007/s00436-018-5754-5.

Ferreira SCM*, Torelli F*, Klein S, Fyumagwa R, Hofer H, Seeber F, Karesh WB, East ML. (2018).
Evidence of high exposure to Toxoplasma gondii in free-ranging and captive African carnivores
Int J Parasitol Parasites Wildl 8:111-7. doi.org/10.1016/j.ijppaw.2018.12.007. *equal contribution

Helmy YA, Spierling NG, Schmidt S, Rosenfeld UM, Reil D, Imholt C, Jacob J, Ulrich RG, Aebischer T, Klotz C. (2018).
Occurrence and distribution of Giardia species in wild rodents in Germany.
Parasit Vectors 11:213. doi: 10.1186/s13071-018-2802-z.

Horchler L, Gisder S, Boecking O, Genersch E. (2018).
Diagnostic value of faecal spots on and in honey bee (Apis mellifera) hives.
Berl Münch Tierärztl Wochenschr 131. doi: 10.2376/0005-9366-18035.

Kong P, Lehmann MJ, Helms JB, Brouwers JF, Gupta N. (2018).
Lipid analysis of Eimeria sporozoites reveals exclusive phospholipids, a phylogenetic mosaic of endogenous synthesis, and a host-independent lifestyle.
Cell Discov 4:24. doi: 10.1038/s41421-018-0023-4.

Midha A, Janek K, Niewienda A, Henklein P, Guenther S, Serra DO, Schlosser J, Hengge R, Hartmann S. (2018).
The intestinal roundworm Ascaris suum releases antimicrobial factors which interfere with bacterial growth and biofilm formation.
Front Cell Infect Microbiol 8:271. doi: 10.3389/fcimb.2018.00271.

Midha A, Janek K, Niewienda A, Henklein P, Guenther S, Serra DO, Schlosser J, Hengge R, Hartmann S. (2018).
Corrigendum: The Intestinal Roundworm Ascaris suum Releases Antimicrobial Factors Which Interfere With Bacterial Growth and Biofilm Formation.
Front Cell Infect Microbiol 8:367. doi: 10.3389/fcimb.2018.00367.

Prüter H, Czirják GÁ, Twietmeyer S, Harder T, Grund C, Mühldorfer K, Lüschow D. (2018).
Sane and sound - a serologic and genetic survey for selected infectious agents in neozootic Egyptian geese (Alopochen aegyptiacus) in Germany.
Eur J Wildlife Res 64:71. doi: 10.1007/s10344-018-1231-9.

Prüter H, Franz M, Auls S, Czirják GA, Greben O, Greenwood A D, Lisitsyna O, Syrota Y, Sitko J, Krone O. (2018).
Chronic lead intoxication decreases intestinal helminth species richness and infection intensity in mallards (Anas platyrhynchos).
Sci Total Environ 644:151-60. doi: 10.1016/j.scitotenv.2018.06.297.

Rausch S, Midha A, Kuhring M, Affinass N, Radonic A, Kühl AA, Bleich A, Renard BY, Hartmann S. (2018).
Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation.
Front Immunol 9:2282. doi: 10.3389/fimmu.2018.02282.

Torelli F, Zander S, Ellerbrok H, Kochs G, Ulrich RG, Klotz C, Seeber F. (2018).
Recombinant IFN-γ from the bank vole Myodes glareolus: a novel tool for research on rodent reservoirs of zoonotic pathogens.
Sci Rep 8: 2797. doi: 10.1038/s41598-018-21143-0.

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE. (2018).
Recognition of microbial viability via TLR8 drives T_FH cell differentiation and vaccine responses.
Nat Immunol 19: 386–96. doi:10.1038/s41590-018-0068-4.

Wedam J, Tacoli C, Gai PP, Siegert K, Kulkarni SS, Rasalkar R, Boloor A, Jain A, Mahabala C, Baliga S, Shenoy D, Devi R, Gai P, Mockenhaupt FP. (2018).
Molecular evidence for Plasmodium falciparum resistance to sulfadoxine-pyrimethamine but absence of K13 mutations in Mangaluru, southwestern India.
Am J Trop Med Hyg 99:1508-10. doi: 10.4269/ajtmh.18-0549.

Yordanova I*, Zakovic S*, Rausch S, CostaG, Levashina E, Hartmann S. (2018).
Micromanaging immunity in the murine hosts versus mosquito vectors: microbiota-dependent immune responses to intestinal parasites.
Front Cell Infect Microbiol 8:308. doi: 10.3389/fcimb.2018.0030. *equal contribution

Zakovic S, Levashina EA.(2018).
Insects Go on a STING Operation to Tackle Intracellular Invaders.
Immunity 49:195-7. doi: 10.1016/j.immuni.2018.08.003.

Publications in 2017

Ahmed N, French T, Rausch S, Kühl A, Hemminger K, Dunay I, Steinfelder S, Hartmann S. (2017).
Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.
Front Cell Infect Microbiol 7:1–12. doi: 10.3389/fcimb.2017.00341.

Bock C, Babu S, Breloer M, Rajamanickam A, Boothra Y, Brunn ML, Kühl AA, Merle R, Löhning M, Hartmann S, Rausch S. (2017).
Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells.
Front Cell Infect Microbiol 7: 1–15. doi: 10.3389/fcimb.2017.00261.

Bredtmann C, Krücken J, Murugaiyan J, Kuzmina T, von Samson-Himmelstjerna G. (2017).
Nematode Species Identification—Current Status, Challenges and Future Perspectives for Cyathostomins.
Front Cell Infect Microbiol 7: 283. doi: 10.3389/fcimb.2017.00283.

Costantini D, Wachter B, Melzheimer J, Czirják GÁ. (2017).
Socioecological and environmental predictors of physiological stress markers in a threatened feline species.
Conserv Physiol 5: cox069. doi:10.1093/conphys/cox069.

Ehret T, Torelli F, Klotz C, Pedersen AB, Seeber F. (2017).
Translational Rodent Models for Research on Parasitic Protozoa-A Review of Confounders and Possibilities.
Front Cell Infect Microbiol 7:238. doi: 10.3389/fcimb.2017.00238.

Ehret T, Spork S, Dieterich C, Lucius R, Heitlinger E. (2017).
Dual RNA-seq reveals no plastic transcriptional response of the coccidian parasite Eimeria falciformis to host immune defenses.
BMC Genomics 18:686. doi: 10.1186/s12864-017-4095-6.PMC5584376.

Gisder S, Schüler V, Horchler LL, Groth D, Genersch E. (2017).
Long-Term Temporal Trends of Nosema spp. Infection Prevalence in Northeast Germany: Continuous Spread of Nosema ceranae, an Emerging Pathogen of Honey Bees (Apis mellifera), but No General Replacement of Nosema apis.
Front Cell Infect Microbiol 7: 301. doi: 10.3389/fcimb.2017.00301.

Heitlinger E*, Ferreira SCM*, Thierer D, Hofer H, East ML. (2017).
The Intestinal Eukaryotic and Bacterial Biome of Spotted Hyenas: The Impact of Social Status and Age on Diversity and Composition.
Front Cell Infect Microbiol 7:262. doi: 10.3389/fcimb.2017.00262. *equal contribution

Jaurigue J, Seeberger PH. (2017).
Parasite Carbohydrate Vaccines.
Front Cell Infect Microbiol 7:248. doi: 10.3389/fcimb.2017.00248.

Heinrich SK, Hofer H, Courtiol A, Melzheimer J, Dehnhard M, Czirják GÁ*, Wachter B*. (2017).
Cheetahs have a stronger constitutive innate immunity than leopards.
Sci Rep 7:44837. doi: 10.1038/srep44837. *equal contribution.

Kofer J, Hofer H, Hartmann S. (2017).
Next-Generation Parasitologists: Structured Training Programs Meet Educational Challenges.
Trends Parasitol 33:423–5. doi: 10.1016/j.pt.2017.03.008.

Kraft MR, Klotz C, Bücker R, Schulzke JD, Aebischer T. (2017).
Giardia's Epithelial Cell Interaction In Vitro: Mimicking Asymptomatic Infection?
Front Cell Infect Microbiol 7:421. doi: 10.3389/fcimb.2017.00421.

Kreutzfeld O, Müller K, Matuschewski K. (2017).
Engineering of Genetically Arrested Parasites (GAPs) For a Precision Malaria Vaccine.
Front Cell Infect Microbiol 7: 198. doi: 10.3389/fcimb.2017.00198.

Midha A, Schlosser J, Hartmann S. (2017).
Reciprocal Interactions between Nematodes and Their Microbial Environments.
Front Cell Infect Microbiol 7:144. doi: 10.3389/fcimb.2017.00144.

Yilmaz E, Ramünke S, Demeler J, Krücken J. (2017).
Comparison of constitutive and thiabendazole-induced expression of five cytochrome P450 genes in fourth-stage larvae of Haemonchus contortus isolates with different drug susceptibility identifies one gene with high constitutive expression in a multi-resistant isolate.
Int J Parasitol Drugs Drug Resist 7:362-9. doi: 10.1016/j.ijpddr.2017.10.001.

Zakovic S, Levashina EA. (2017).
NF-κB-Like Signaling Pathway REL2 in Immune Defenses of the Malaria Vector Anopheles gambiae.
Front Cell Infect Microbiol. 7:258. doi: 10.3389/fcimb.2017.00258.

Publications in 2016

Maaz D, Rausch S, Richter D, Krücken J, Kühl AA, Demeler J, Blümke J, Matuschka FR, von Samson-Himmelstjerna G, Hartmann S. (2016).
Susceptibility to ticks and Lyme disease spirochetes is not affected in mice co-infected with nematodes.
Infect Immun 84:1274–86. doi: 10.1128/IAI.01309-15.

Seeber F, Steinfelder S. (2016).
Recent advances in understanding apicomplexan parasites.
F1000Res 5:F1000 Faculty Rev-1369. doi: 10.12688/f1000research.7924.1.

Tacoli C, Gai PP, Bayingana C, Sifft K, Geus D, Ndoli J, Sendegeya A, Gahutu JB, Mockenhaupt FP. (2016).
Artemisinin Resistance-Associated K13 Polymorphisms of Plasmodium falciparum in Southern Rwanda, 2010-2015.
Am J Trop Med Hyg 95:1090-3. doi: 10.4269/ajtmh.16-0483.

mSphere Aug 14:e0047824. doi: 10.1128/msphere.00478-24

Public outreach

"wir" - the Magazine for Alumni of the Freie Universität Berlin issue Winter 2022/2023, pages 26-33: "Veterinärmedizinische Diversität in Berlin"

Deutsche Welle, Interview with Welmoed van Loon (project C7), 6 January 2023: "Antimalarial drug resistance on the rise in Africa"

Read the interview

Veterinärmedizin in der Hauptstadt (VidH) issue 38/39-2021, pages 35-36: "Das Graduiertenkolleg über Parasiteninfektionen in Zeiten der Viruspandemie"

Veterinärmedizin in der Hauptstadt (VidH) issue 34/35-2019, pages 40-42: "Einschneidende Erlebnisse des Graduiertenkolleg 2046 in 2019"

1) Begutachtung und Folgebewilligung bis 2024
2) Parasiten bei Wildtieren – moderne Technik im Serengeti National Park

Veterinärmedizin in der Hauptstadt (VidH) issue 32/33-2018, pages 33-34: "Graduiertenkolleg 2046: Die zweite Doktorandengeneration ist gestartet"

... und der Folgeantrag für die Laufzeit 2019-2024 wurde eingereicht.

Veterinärmedizin in der Hauptstadt (VidH) issue 30/31-2017, pages 27-28: "Botschafter der Parasitologie: GRK 2046 Studenten tragen ihre Ergebnisse in die Welt und laden Wissenschaftler aus der ganzen Welt nach Berlin ein"

Veterinärmedizin in der Hauptstadt (VidH) issue 28/29-2016, pages 36-37: "Zebras, Gazellen, Tüpfelhyänen & Co"

Tagesspiegel, 3 December 2016, page B5: "Forscher, die auf Zebras starren"

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School of Veterinary Medicine

Research Training Group 2046 "Parasite Infections: From Experimental Models to Natural Systems"