Member since: Januar 2019

Research interest
Pathogen-host interactions

Title of PhD project
Giardia duodenalis –mimicking cognate interaction conditions and outcome on human intestinal barrier function

Supervisors
Dr. Anton Aebischer and Dr. Christian Klotz

Weiß F, Holthaus D, Kraft M, Klotz C, Schneemann M, Schulzke JD, Krug SM. (2022).
Human duodenal organoid-derived monolayers serve as a suitable barrier model for duodenal tissue.
Ann N Y Acad Sci 1515:155-67. doi: 10.1111/nyas.148045.

Warschkau D, Delgado Betancourt E, Holthaus D, Müller A, Kliem G, Krug SM, Schulzke JD, Aebischer T, Klotz C, Seeber F. (2022).
From 3D to 2D: Harmonization of Protocols for Two-dimensional Cultures on Cell Culture Inserts of Intestinal Organoids from Various Species.
Bio Protoc 12:e4295. doi: 10.21769/BioProtoc.4295.

Holthaus D*, Kraft MR*, Krug SM, Wolf S, Müller A, Delgado Betancourt E, Schorr M, Holland G, Knauf F, Schulzke JD, Aebischer T^§, Klotz C^§. (2022).
Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis.
Gastroenterology 162:844-58. doi: 10.1053/j.gastro.2021.11.022. *^/§equal contribution

Holthaus D, Delgado-Betancourt E, Aebischer T, Seeber F, Klotz C. (2021).
Harmonization of Protocols for Multi-Species Organoid Platforms to Study the Intestinal Biology of oxoplasma gondii and Other Protozoan Infections.
Front Cell Infect Microbiol 10:610368. doi: 10.3389/fcimb.2020.610368.