Member since: May 2018

Research interest
Innate immune responses of intestinal organoids from wild rodents upon Toxoplasma gondii infection

Title of PhD project
Comparative analysis of innate immune responses of intestinal organoids from wild rodents upon infection: Challenging the Toxoplasma gondii / house mouse model

Supervisor
Prof. Dr. Frank Seeber

Warschkau D, Delgado Betancourt E, Holthaus D, Müller A, Kliem G, Krug SM, Schulzke JD, Aebischer T, Klotz C, Seeber F. (2022).
From 3D to 2D: Harmonization of Protocols for Two-dimensional Cultures on Cell Culture Inserts of Intestinal Organoids from Various Species.
Bio Protoc 12:e4295. doi: 10.21769/BioProtoc.4295.

Holthaus D*, Kraft MR*, Krug SM, Wolf S, Müller A, Delgado Betancourt E, Schorr M, Holland G, Knauf F, Schulzke JD, Aebischer T^§, Klotz C^§. (2022).
Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis.
Gastroenterology 162:844-58. doi: 10.1053/j.gastro.2021.11.022. *^/§equal contribution

Holthaus D, Delgado-Betancourt E, Aebischer T, Seeber F, Klotz C. (2021).
Harmonization of Protocols for Multi-Species Organoid Platforms to Study the Intestinal Biology of oxoplasma gondii and Other Protozoan Infections.
Front Cell Infect Microbiol 10:610368. doi: 10.3389/fcimb.2020.610368.

Delgado Betancourt E, Hamid B, Fabian BT, Klotz C, Hartmann S, Seeber F. (2019).
From Entry to Early Dissemination-Toxoplasma gondii's Initial Encounter With Its Host.
Front Cell Infect Microbiol 9:46. doi: 10.3389/fcimb.2019.00046.