Dr. Christian Klotz
Participating researcher in project B3: Giardia duodenalis - Dendritic cell interaction and intestinal barrier function: PhD students David Holthaus (B3-2) and Antonia Müller (B3-3).
Robert Koch Institute
Mycotic and Parasitic Agents and Mycobacteria
Research interest:
- Parasitology
Klotz C, Schmid MW, Winter K, Ignatius R, Weisz F, Saghaug CS, Langeland N, Dawson S, Lalle M, Hanevik K, Cacciò SM, Aebischer T. (2023).
Highly contiguous genomes of human clinical isolates of Giardia duodenalis reveal assemblage- and sub-assemblage-specific presence-absence variation in protein-coding genes.
Microb Genom 9:mgen000963. doi: 10.1099/mgen.0.000963.
Weiß F, Holthaus D, Kraft M, Klotz C, Schneemann M, Schulzke JD, Krug SM. (2022).
Human duodenal organoid-derived monolayers serve as a suitable barrier model for duodenal tissue.
Ann N Y Acad Sci 1515:155-67. doi: 10.1111/nyas.148045.
Warschkau D, Delgado Betancourt E, Holthaus D, Müller A, Kliem G, Krug SM, Schulzke JD, Aebischer T, Klotz C, Seeber F. (2022).
From 3D to 2D: Harmonization of Protocols for Two-dimensional Cultures on Cell Culture Inserts of Intestinal Organoids from Various Species.
Bio Protoc 12:e4295. doi: 10.21769/BioProtoc.4295.
Holthaus D*, Kraft MR*, Krug SM, Wolf S, Müller A, Delgado Betancourt E, Schorr M, Holland G, Knauf F, Schulzke JD, Aebischer T§, Klotz C§. (2022).
Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis.
Gastroenterology 162:844-58. doi: 10.1053/j.gastro.2021.11.022. */§equal contribution
Holthaus D, Delgado-Betancourt E, Aebischer T, Seeber F, Klotz C. (2021).
Harmonization of Protocols for Multi-Species Organoid Platforms to Study the Intestinal Biology of oxoplasma gondii and Other Protozoan Infections.
Front Cell Infect Microbiol 10:610368. doi: 10.3389/fcimb.2020.610368.
Yordanova IA, Cortés A, Klotz C, Kühl AA, Heimesaat MM, Cantacessi C, Hartmann S, Rausch S. (2019).
RORγt+ Treg to Th17 ratios correlate with susceptibility to Giardia infection.
Sci Rep 9:20328. doi: 10.1038/s41598-019-56416-9.
Helmy YA, Spierling NG, Schmidt S, Rosenfeld UM, Reil D, Imholt C, Jacob J, Ulrich RG, Aebischer T, Klotz C. (2018).
Occurrence and distribution of Giardia species in wild rodents in Germany.
Parasit Vectors 11:213. doi: 10.1186/s13071-018-2802-z.
Kraft MR, Klotz C, Bücker R, Schulzke JD, Aebischer T. (2017).
Giardia's Epithelial Cell Interaction In Vitro: Mimicking Asymptomatic Infection?
Front Cell Infect Microbiol 7:421. doi: 10.3389/fcimb.2017.00421.
