Prof. Dr. rer. nat. Susanne Hartmann

Career:
since 10/2015
Professor (W3) for Infection Immunology and Head of the Institute for Immunology at Freie Universität Berlin, Department of Veterinary Medicine, Centre for Infection Medicine.
 
12/2011-11/2016
DFG Heisenberg Professorship (W3) for Infection Immunology at Freie Universität Berlin, Department of Veterinary Medicine, Centre for Infection Medicine.
 
2005 - 2011
Assistant Professor and University Teaching Authorization (venia legendi) at the Institute of Molecular Parasitology at the Humboldt-University Berlin.
 
2004
Habilitation at the Faculty of Mathematics and Science at theHumboldt-University Berlin.
 
1996 – 2004
Group Leader at the Institute of Molecular Parasitology at the Humboldt-University Berlin.
 
1995
Postdoctoral Fellow at the Institute of Parasitology at the University of Stuttgart-Hohenheim.
 
1993
Guest Scientist at the Molecular Parasitology of the medical faculty of the Free University Brussels, Belgium (Prof. Dr. B. Vray).
 
1990 – 1994
Doctoral thesis at the Institute for Parasitology of the University Stuttgart-Hohenheim (Prof. Dr. R. Lucius).
 
Academic Education:
1990                              Diploma in Biology
Diploma thesis performed at the University of Oxford (GB) with Prof. Dr. A. Keymer (University Oxford) and Prof. P. Wenk (University of Tübingen).
 
1986 - 1990                  Graduate studies: Eberhard-Karls-University Tübingen
1987 - 1988                  Studies abroad: University of Oxford (GB)
1984 - 1986                  Undergraduate studies: University of Bremen
 
 
Scholarships/honours:

Member of the National Academy of Sciences "Leopoldina", since 2018
Innovation Award Foundation Familie Klee, 2018
Central Teaching Award of Freie Universität Berlin, 2018
DFG Heisenberg Professorship "Infection Immunology", 12/2011 – 12/2016
PhD scholarship of the graduate program Baden-Württemberg, 1992 - 1994.
Scholarship of the Boehringer-Ingelheim Foundation for a research stay at the University of Brussels, 1993.
Scholarship of the German Academic Exchange Service for studies abroad, 1988.

Susanne Hartmann: Publications

(last update: 16.10.2024)

2024

Leben, R.; Rausch, S.; Elomaa, L.; Hauser, A. E.; Weinhart, M.; Fischer, S. C.; Stark, H.; Hartmann, S.; Niesner, R.; 2024. Aggregation of adult parasitic nematodes in sex-mixed groups analysed by transient anomalous diffusion formalism. IJ. R. Soc. Interface 2120240327. http://doi.org/10.1098/rsif.2024.0327

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Midha, A.; Oser, L.; Schlosser-Brandenburg, J.; Laubschat, A.; Mugo, R. M.; Musimbi, Z. D.; Höfler, P.; Kundik, A.; Hayani, R.; Adjah, J.; Groenhagen, S.; Tieke, M.; Elizalde-Velázquez, L. E.; Kühl, A. A.; Klopfleisch, R.; Tedin, K.; Rausch, S.; Hartmann, S.; 2024. Concurrent Ascaris infection modulates host immunity resulting in impaired control of Salmonella infection in pigs.
mSphere 0:e00478-24. https://doi.org/10.1128/msphere.00478-24

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Elizalde-Velázquez, L. E.; Schlosser-Brandenburg, J.; Laubschat, A.; Oser, L.; Kundik, A.; Adjah, J.; Groenhagen, S.; Kühl, A. A.; Rausch, S.; Hartmann, S.; 2024. Th2-biased immune responses to body migrating Ascaris larvae in primary infection are associated with pathology but not protection. Sci Rep; 14, S. 14919. https://doi.org/10.1038/s41598-024-65281-0

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Mugo, R. M.; Oser, L.; Midha, A.; Adjah, J.; Kundik, A.; Laubschat, A.; Höfler, P.; Musimbi, Z. D.; Hayani, R.; Schlosser-Brandenburg, J.; Hartmann, S.; Rausch, S.; 2024. Acute Ascaris infection impairs the effector functions of natural killer cells in single and Salmonella co-infected pigs. Sci Rep; 14(1), S. 14586. https://doi.org/10.1038/s41598-024-64497-4

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Mugo, R. M.; Rausch, S.; Kidiavai, Z. D. M.; Strube, C.; Raulf, M.-K.; Landt, O.; Gichuki, P. M.; Ebner, F.; Mwacharo, J.; Odiere, M. R.; Ndungu, F. M.; Njomo, D. W.; Hartmann, S.; 2024. Evaluation of copromicroscopy, multiplex-qPCR and antibody serology for monitoring of human ascariasis in endemic settings. PLoS Negl Trop Dis 18(6): e0012279. https://doi.org/10.1371/journal.pntd.0012279

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Oser, L.; Midha, A.; Schlosser-Brandenburg, J.; Rausch, S.; Mugo, R. M.; Kundik, A.; Elizalde-Velázquez, L. E.; Adjah, J.; Musimbi, Z. D.; Klopfleisch, R.; Helm, C. S.; von Samson-Himmelstjerna, G.; Hartmann, S.; Ebner, F.; 2024, Ascaris suum infection in juvenile pigs elicits a local Th2 response in a setting of ongoing Th1 expansion. Front. Immunol. 15; S.*
DOI:  10.3389/fimmu.2024.1396446/full

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Wolstenholme, A. J.; Andersen, E. C.; Choudhary, S.; Ebner, F.; Hartmann, S.; Holden-Dye, L.; Kashyap, S. S.; Krücken, J.; Martin, R. J.; Midha, A.; Nejsum, P.; Neveu, C.; Robertson, A. P.; von Samson-Himmelstjerna, G.; Walker, R.; Wang, J.; Whitehead, B. J.; Williams, P. D. E.; 2024, Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids. Adv Parasitol; 123; S. 51–123, DOI: 10.1016/bs.apar.2023.12.002

2023

Liublin, W.; Rausch, S.; Leben, R.; Liebeskind, J.; Hauser. A.E.; Hartmann, S.; Niesner, R.A.; 2023
NAD(P)H Fluorescence Lifetime Imaging for the Metabolic Analysis of the Murine Intestine and Parasites During Nematode Infection. J Vis Exp Sep 1;(199). DOI: 10.3791/64982

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Kundik, A.; Musimbi, Z. D.; Krücken, J.; Hildebrandt, T.; Kornilov, O.; Hartmann, S.; Ebner, F.; 2023
Quantifying metabolic activity of Ascaris suum L3 using resazurin reduction. Parasit Vectors; 16:243,
DOI: 10.1186/s13071-023-05871-5

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Schlosser-Brandenburg, J.; Midha, A.; Mugo, R. M.; Ndombi, E. M.; Gachara, G.; Njomo, D.; Rausch, S.; Hartmann, S.; 2023. Infection with soil-transmitted helminths and their impact on coinfections. Frontiers in parasitology; 2, S. Artikel 1197956, DOI: 10.3389/fpara.2023.1197956

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Elizalde‐Velázquez, L. E.; Yordanova, I. A.; Liublin, W.; Adjah, J.; Leben, R.; Rausch, S.; Niesner, R.; Hartmann, S.; 2023. Th2 and metabolic responses to nematodes are independent of prolonged host microbiota abrogation. Parasite Immunology; 45(4 : Special Issue: Parasites and the Microbiota), S. Artikel e12957, DOI: 10.1111/pim.12957

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Yordanova, I. A.; Elizalde‐Velázquez, L. E.; Hartmann, S; 2023. Immunization with excretory‐secretory molecules of intestinal nematodes induces antigen‐specific protective memory Th2 cell responses. Eur. J. Immunol., Accepted Author Manuscript 2250237, DOI: 10.1002/eji.202250237

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Grzeskowiak, L,...Hartmann, S, … Zentek, J; 2023 Dietary fibre and its role in performance, welfare and health of pigs. Anim. Health Res. Rev., S-1-29, DOI: 10.1017/S1466252322000081

 

2022

Midha, A; Jarquín-Díaz, VH; Ebner, F; Löber, U; Hayani, V; Kundik, A; Cardilli, A; Heitlinger, E; Forslund, S.K; Hartmann, S; 2022. Guts within guts: The microbiome of the intestinal helminth parasite Ascaris suum is derived but distinct from its host.Microbiome 10 (1), DOI: 10.1186/s40168-022-01399-5

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Elizalde-Velázquez, LE; Yordanova, IA; Liublin, W; Adjah, J; Leben, R; Rausch, S; Niesner, R; Hartmann, S; 2022. Th2 and metabolic responses to nematodes are independent of prolonged host microbiota abrogation Parasite Immunol Nov 17;e12957 DOI: 10.1111/pim.12957

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Hamid, B; Ebner, F; Bechtold, L; Kundik, A; Rausch, S; Hartmann, S; 2022. Ascaris suum excretory/secretory products differentially modulate porcine dendritic cell subsets. Front. Immunol.; 13, S.1012717, DOI: 10.3389/fimmu.2022.1012717

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Yordanova, IA; Jürchott, K; Steinfelder, S; Vogt, K; Krüger, U; Kühl, AA; Sawitzki, B; Hartmann, S; 2022. The host peritoneal cavity harbors prominent memory Th2 and early recall responses to an intestinal nematode. Front. Immunol. 13, DOI: 10.3389/fimmu.2022.842870

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Liublin, W; Rausch, S; Leben, R; Lindquist, RL; Fiedler, A; Liebeskind, J; Beckers, IE; Hauser, AE; Hartmann, S; Niesner. R.A; 2022. NAD(P)H fluorescence lifetime imaging of live intestinal nematodes reveals metabolic crosstalk between parasite and host Sci Rep 12. DOI: 10.1038/s41598-022-10705-y

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Zhang, HW; Bednář, L; Heitlinger, E; Hartmann S; Rausch, S; 2022. Whip- and pinworm infections elicit contrasting effector and distinct regulatory responses in wild house mice. Int J Parasitol 52 (8): 519-524, DOI: 10.1016/j.ijpara.2022.03.006

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Kapse, B; Zhang, HW; Affinass, N; Ebner, F; Hartmann, S; Rausch, S; 2022 Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection, Mucosal Immunol, DOI: 10.1038/s41385-022-00519-6

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Kaplonek, P; Yao, L; Reppe, K; Voß, F; Kohler, T; Ebner, F; Schäfer, A; Blohm, U; Priegue, P; Bräutigam, M; Pereira, C.L; Parameswarappa, S.G; Emmadi, M; Ménová, P; Witzenrath, M; Hammerschmidt, S; Hartmann, S; Sander, L.E; Seeberger, P.H: 2022. A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae, Vaccine; 40(7), S. 1038–1046, DOI: 10.1016/j.vaccine.2021.12.068

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Vorträge

International Congress of Parasitology and World Federation of Parasitologists, 21-26. August 2022, Copenhagen, Denmark. Susanne Hartmann: „Microbiome-associated Ascaris-host interactions.”

 Scientific Symposium: Anti-Infective Resistance in animal pathogens: causes, significance and approaches to solutions. Berlin, 19-20 September 2022, Berlin. Susanne Hartmann: „Regulation of gut microbes by intestinal worms and benefit from microbiota-driven immune modulation.”

 Leopoldina Annual Conference 2022. Global Health: From Health Services to Climate Change and to Social Justice. 23-24. September 2022. Susanne Hartmann: “Parasites: Drivers and Brakemen of the Global-Disease-Burden. “

 Scientific Seminar: Helminths and Helminth Co-Infections. 31^st October 2022. Kenyatta University Nairobi, Kenya. Susanne Hartmann: “Parasitic Helminths: Immunoregulation and Microbial Interactions”.

 Scientific Seminar: Helminths Infections and Social Science Aspects. 1^st November 2022. KEMRI-Eastern and Southern Africa Centre of International Parasite Control (ESACIPAC), Nairobi, Kenya. Susanne Hartmann: “Parasitic Helminths and Immunoregulation”.

Scientific Seminar: Helminth Infection. 2^nd November 2022. KEMRI-Center for Global Health Research (CGHR), Kisumu, Kenya. Susanne Hartmann: “Immunoregulation and microbial interaction of parasitic nematodes”.

 

2021

Ebner, F.; Lindner, K.; Janek, K.; Niewienda, A.; Malecki, P. H.; Weiß, M. S.; Sutherland, T. E.; Heuser, A.; Kühl, A. A.; Zentek, J.; Hofmann, A.; Hartmann, S. (2021)
A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease
Journal of Immunology Research 2021, 24 pages, epub
doi:10.1155/2021/6234836

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Hamid, B.; Schlosser-Brandenburg, J.; Bechtold, L.; Ebner, F.; Rausch, S.; Hartmann, S. (2021)
Early immune initiation by porcine cells following Toxoplasma gondii infection versus TLR ligation.
Microorganisms 2021; 9(9):1828
doi:10.3390/microorganisms9091828

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Schlosser-Brandenburg, J.; Ebner, F.; Klopfleisch, R.; Kühl, A. A.; Zentek, J.; Pieper, R.; Hartmann, S. (2021)
Influence of nutrition and maternal bonding on postnatal lung development in the newborn pig.
Front. Immunol. 2021, 12:3144
doi: 10.3389/fimmu.2021.734153

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Midha, A., Goyette-Desjardins, G., Gordeler, F., Mocovitz, O., Seeberger, P. H., Tedin, K., Bertzbach, L. D., Lepenies, B., Hartmann, S. (2021)
Lectin-mediated bacterial modulation by the intestinal nematode Ascaris suum.
Int. J. Mol. Sci  2021, 22(16):8739
doi: 10.3390/ijms22168739

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Midha, A.; Ebner, F.; Schlosser-Brandenburg, J.; Rausch, S.; Hartmann, S. (2021)
Trilateral relationship: ascaris, microbiota, and host cells.
Trends Parasitol. 2021, 37(3):251–262
doi: 10.1016/j.pt.2020.09.002

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Yordanova, I.A.; Ebner, F.; Schulz, A.R.; Steinfelder, S.; Rosche, B.; Bolze, A.; Paul, F.; Mei, H.E.; Hartmann, S.(2021)
The Worm-Specific Immune Response in Multiple Sclerosis Patients Receiving Controlled Trichuris suis Ova Immunotherapy. Life 2021, 11(2):101
doi: 10.3390/life11020101

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Vorträge

Keynote lecture: S. Hartmann. Parasitic Nematodes: Immunoregulation and Microbial Interaction. 29th Annual Meeting of the German Society for Parasitology, 15.-17. March Bonn, 2021

Invited speaker. S. Hartmann. Immunoregulation by Parasitic Nematodes. KEMRI Seminar Series, Kilifi Kenia. 5^th July 2021

Invited speaker: S. Hartmann. Intestinal nematodes release antimicrobial and benefit from microbiota-driven immune regulation. European Multicolloquium for Parasitology (EMOP) 12.-16. October 2021, Belgrade

Invited speaker: S. Hartmann. Ascaris – immune response – microbiota triangle. Le Studium Conference. New approaches to get around roundworms. The Ascarid Research and Training Initiative (ARTI) 29.11.-1.12.2021

2020

Midha, A.; Ebner, F.; Schlosser-Brandenburg, J.; Rausch, S.; Hartmann, S. (2020)
Trilateral relationship: Ascaris, microbiota, and host cells.
Trends in parasitology, S. 2049
doi: 10.1016/j.pt.2020.09.002

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Yordanova, I. A.; Lamatsch, M.; Kühl, A. A.; Hartmann, S.; Rausch, S. (2020)
Eosinophils are dispensable for the regulation of IgA and Th17 responses in Giardia muris infection.
Parasite Immunol, S. e12791
doi: 10.1111/pim.12791

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Schmidt, St.; Ebner, F.; Rosen, K.; Kniemeyer, O.; Brakhage, A. A.; Löffler, J.; Seif, M.; Springer, J.; Schlosser, J.; Scharek-Tedin, L.; Scheffold, A.; Bacher, P.; Kühl, A.A.; Rösler, U.; Hartmann, S. (2020)
The domestic pig as human‐relevant large animal model to study adaptive anti‐fungal immune responses against
airborne Aspergillus fumigatus
Eur. J. Immunol.; xx:1
doi: 10.1002/eji.201948524

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Rosen, K.; Ebner, F.; Schmidt, S.; Hartmann, S.; Merle, R.; Friese, A.; Roesler, U. (2020)
Influence of Immune Status on the Airborne Colonization of Piglets with Methicillin-Resistant Staphylococcus aureus (MRSA) Clonal Complex (CC) 398
Eur J Microbiol Immunol;10:1
doi: 10.1556/1886.2019.00024

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Ebner, F.; Morrison, E.; Bertazzon, M.; Midha, A.; Hartmann, S.; Freund, C.; Álvaro-Benito, M. (2020)
CD4⁺ T_h immunogenicity of the Ascaris spp. secreted products.
npj Vaccines; 5:25
doi: 10.1038/s41541-020-0171-z

 

2019

Yordanova I.A.; Cortés A.; Klotz C., Kühl A.A.; Heimesaat M.M.; Cantacessi C.; Hartmann S.; Rausch S. (2019)
RORγt⁺ Treg to Th17 ratios correlate with susceptibility to Giardia infection.
Sci Rep 9(1), 20328
doi: 10.1038/s41598-019-56416-9

Cossarizza, A.; ... Hartmann S.; ... Zychlinsky, A. (2019)
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Eur. J. Immunol. 49:1457–1973
doi: 10.1002/eji.201970107

Ahmed N, Nicole Affinass, Emanuel Heitlinger, Anja A. Kühl, Natasa Xenophontos, Victor H. Jarquin, Jenny Jost, Svenja Steinfelder, Susanne Hartmann (2019)
A novel non-invasive method to detect RELM beta transcript in gut barrier related changes during a gastrointestinal nematode infection.
Front. Immunol. 10:445
doi: 10.3389/fimmu.2019.00445

Delgado Betancourt, E.; Hamid, B.; Fabian, B. T.; Klotz, C.; Hartmann, S.; Seeber, F. (2019)
From Entry to Early Dissemination-Toxoplasma gondii's Initial Encounter With Its Host.
Front Cell Infect Microbiol.; 9:46.
doi: 10.3389/fcimb.2019.000469

French, T.; Düsedau, H. P.; Steffen, J.; Biswas, A.; Ahmed, N.; Hartmann, S.; Schüler, T.; Schott, B. H.; Dunay, I. R. (2019):
Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner.
J. Neuroinflammation; 16(1), p. 159
doi: 10.1186/s12974-019-1539-8

Venugopal, G.; O'Regan, N. L.; Babu, S.; Schumann, R. R.; Srikantam, A.; Merle, R.; Hartmann, S.; Steinfelder, S. (2019):
Association of a PD-L2 Gene Polymorphism with Chronic Lymphatic Filariasis in a South Indian Cohort.
Am J Trop Med Hyg. 100(2):344–350
doi: 10.4269/ajtmh.18-0731

2018

Rausch, S.; Midha, A.; Kuhring, M.; Affinass, N.; Radonic, A.; Kühl, A. A.; Bleich, A.; Hartmann, S. (2018):
Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation.Frontiers in immunology, www.frontiersin.org/articles/10.3389/fimmu.2018.02282/

Yordanova, I.; Zakovic, S.; Rausch, S.; Costa, G.; Levashina, E.; Hartmann, S. (2018): Micromanaging immunity in the murine host versus the mosquito vector: microbiota-dependent immune responses to intestinal parasites.Frontiers in cellular and infection microbiology, doi: 10.3389/fcimb.2018.00308

Midha, A.; Janek, K.; Niewienda, A.; Henklein, P.; Günther, S.; Serra, D. O.; Schlosser, J.;
Hengge, R.; Hartmann, S. (2018): The Intestinal Roundworm Ascaris suum Releases Antimicrobial Factors Which Interfere With Bacterial Growth and Biofilm Formation. Frontiers in cellular and infection microbiology; 8, doi: 10.3389/fcimb.2018.00271,

Affinass, N.; Zhang, H.; Löhning, M.; Hartmann, S.; Rausch, S. (2018):Manipulation of the balance between Th2 and Th2/1 hybrid cells affects parasite nematode fitness in mice.European journal of immunology, S. 7

Ebner, F.; Kuhring, M.; Radonic, A.; Midha, A.; Renard, B. Y.; Hartmann, S. (2018):Silent
Witness: Dual-Species Transcriptomics Reveals Epithelial Immunological Quiescence to Helminth Larval Encounter and Fostered Larval Development.Frontiers in immunology; 9, doi: 10.3389/fimmu.2018.01868

Aebischer, T., K. Matuschewski, S. Hartmann. 2018. Editorial to research topic: „Parasite Infections: From Experimental Models to Natural Systems“. Frontiers in Cellular and Infection Microbiology, doi: 10.3389/fcimb.2018.00012

Maaz D., J. Krücken, J. Blümke, D. Richter, J. Demeler, F.-R. Matuschka, S. Hartmann, G.
von Samson-Himmelstjerna. 2018. Factors associated with the diversity and quantity of
ectoparasites on urban mice and voles. Accepted PLOS One am 15.06.18

Venugopal G., R.R. Noelle L. O’Regan, Schumann, A. Srikantum, R. Merle, S. Hartmann, S.
Steinfelder. 2018. Association of a PD-L2 gene polymorphism with chronic lymphatic filariasis
in a South Indian cohort. Eingereicht 2 März 2018 bei PLOS One.

Ugolini et al. …… Hartmann, S , L. Sander. 2018. Recognition of microbial viability via
TLR8 drives TFHcell differentiation and vaccine responses. Nature Immunology; 19: 386–396.
DOI:10.1038/s41590-018-0068-4 ; PMID:29556002

2017
Ahmed, N., T. French, S. Rausch, A. A. Kühl, K. Hemminger, I. R. Dunay, S. Steinfelder, S.
Hartmann. 2017. Toxoplasma co-infection prevents Th2 differentiation and leads to a
helminth-specific Th1 response. Frontiers in Cellular and Infection Microbiology,
doi:10.3389/fcimb.2017.00341.

Ebner, F., P. Schwiertz, S. Steinfelder, R. Pieper, J. Zentek, N. Schütze, C. G. Baums, G.
Alber, P. Geldhof, S. Hartmann. 2017. Pathogen-reactive T helper cell analysis in the Pig,
Frontiers in Immunology, doi: 10.3389/fimmu.2017.00565.

Kofer, J., H. Hofer, S. Hartmann. 2017. Next-Generation Parasitologists: Structured Training
Programs Meet Educational Challenges. Trends in Parasitology, 33: 423-425.

Midha, A., J. Schlosser, S. Hartmann. 2017. Reciprocal Interactions between Nematodes and
Their Microbial Environments. Frontiers in Cellular and Infection Microbiology, doi:
10.3389/fcimb.2017.00144

Steinfelder, S., S. Rausch, D. Michael, A. A. Kühl, S. Hartmann. 2017. Intestinal helminth
infection induces highly functional resident memory CD4+ T cells. Eur. J. Immunol., 47:353-
363; doi:10.1002/eji.201646575.

Lindner, J., S. Rausch, S. Treptow, K. Geldmeyer-Hilt, R. St-Arnaud, A. Arabian, A. Radbruch,
S. Hartmann, M. Worm, G. Heine. 2017. Endogenous calcitriol synthesis controls the humoral
IgE response in mice, Journal of Immunology, doi: 10.4049/jimmunol.1602080.

Venugopal G., M. Müller, S. Hartmann, S. Steinfelder. 2017. Differential immunomodulation in
human monocytes versus macrophages by filarial cystatin. PLOS One, doi:
10.1371/journal.pone.0188138.

Bock, C.N., S. Babu, M. Breloer, A. Rajamanickam, Y. Bhootra, M.-L. Brunn, A. A. Kühl, R.
Merle, M. Löhning, S. Hartmann, S. Rausch. 2017. Th2/1 hybrid cells occurring in murine and
human strongyloidiasis share effector functions of Th1 cells, Frontiers in Cellular and Infection
Microbiology, doi: 10.3389/fcimb.2017.00261.

Volkmann, M., J. Steiner, G. Fosgate, J. Zentek, S. Hartmann, B. Kohn. 2017. Chronic
diarrhea in dogs - retrospective study in 136 cases, Journal of Veterinary Internal Medicine,
31:1043-1055.

2016
Strandmark, J., S. Steinfelder, C. Berek, A. Kühl, S. Rausch, S. Hartmann. 2016. Eosinophils
are required to suppress Th2 responses in Peyer’s patches during intestinal infection by
nematodes. Mucosal Immunology, doi:10.1038/mi.2016.93.
Strandmark J., S. Rausch, S. Hartmann. 2016. Eosinophils in homeostasis and their
contrasting roles during inflammation and helminth infections. Critical Reviews in Immunology,
DOI: 10.1615/CritRevImmunol.2016018726.
Steinfelder, S., N.L. O’Regan, S. Hartmann. 2016. Diplomatic Assistance: Can Helminth
modulated macrophages act as treatment for inflammatory disease, PLoS Pathogens,
DOI:10.1371
Maaz, D., S. Rausch, D. Richter, J. Krücken, A.A. Kühl, J. Demeler, J. Blümke, F.R.
Matuschka, G. von Samson-Himmelstjerna, S. Hartmann. 2016. Susceptibility to ticks and
lyme disease spirochetes is not affected in mice coinfected with nematodes. Infection and
Immunity, 84: 1274-1286.
Schuijs MJ, Hartmann S, Selkirk ME, Roberts LB, Openshaw PJ, Schnoeller C. 2016. The
Helminth-Derived Immunomodulator AvCystatin Reduces Virus Enhanced Inflammation by
Induction of Regulatory IL-10+ T Cells. PLoS One. 11:e0161885.
Behrendt, P., P. Arnold, M. Brueck, U. Rickert, R. Lucius, S. Hartmann, C. Klotz, R. Lucius.
2016. A Helminth protease inhibitor modulates lipopolysaccharide-induced proinflammatory
phenotype of microglia in vitro. Neuroimmunomodulation, DOI:10.1159/000444756.

2015
Ziegler, T., S. Rausch, S. Steinfelder, C. Klotz, M.R. Hepworth, A. Kühl, P-C- Burda, R. Lucius,
S. Hartmann. 2015. A novel regulatory macrophage (Mreg) induced by a helminth molecule
instructs IL-10 in CD4+ T-cells and protects against mucosal inflammation, J. Immunology,
194:1555-1564.
Schlundt, C., T. El Khassawana, A. Serra, A. Dienelt, S. Wendler, H. Schell, N. van Rooijen, A.
Radbruch, R. Lucius, S. Hartmann, G.N. Duda, K. Schmidt-Bleek. 2015. Macrophages in
bone fracture healing: Their essential role in endochondral ossification. Bone, DOI:10.019.

2014
Volkmann, M., M.R. Hepworth, F. Ebner, S. Rausch, B. Kohn, S. Hartmann. 2014.
Frequencies of CD4+CD25+Foxp3+ lymphocytes in peripheral blood of dogs with primary
immune-mediated thrombocytopenia and chronic idiopathic enteropathy: a pilot study, The
Veterinary Journal, 202:630-633.
O’Regan, N.L, S. Steinfelder, G. Venugopal, G.B. Rao, R. Lucius, A. Srikantam, S. Hartmann.
2014. Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that
suppresses innate and adaptive immune responses. PLoS NTD, 8:e3206.doi:10.1371.
Ebner, F., M. R. Hepworth, S. Rausch, K. Janek, A. Niewienda, A. Kühl, P. Henklein, R.
Lucius, E. Hamelmann, S. Hartmann. 2014. Therapeutic potential of larval excretory,
secretory proteins of the pig whipworm Trichuris suis in allergic disease. Allergy, 69:1489-
1497.
O'Regan, N. L. S. Steinfelder, C. Schwedler, G. B. Rao, A. Srikantam, V. Blanchard, S.
Hartmann. 2014. Filariasis asymtomatically infected donors have lower levels of disialylated
IgG compared to endemic normals. Parasite Immunol., 36:713-720.
Whelan, R., S. Rausch, F. Ebner, J. Richter, N. Hering, D. Günzel, J.-D. Schulzke, A. Kühl, P.
Janczyk, K. Nöckler, L. Wieler, S. Hartmann. 2014. A novel therapy via a transgenic probiotic
secreting a parasite immunomodulator for site-directed treatment of gut inflammation.
Molecular Therapy, 22:1730-1740.
Ebner, F., S. Rausch, L. Scharek-Tedin, R. Pieper, M. Burwinkel, J. Zentek, S. Hartmann.
2014. A novel lineage transcription factor based analysis reveals differences in T helper cell
subpopulation development in infected and intrauterine growth restricted (IUGR) piglets.
Developmental and Comparative Immunology, 46:333-340.
Schwartz, C., A. Turqueti-Neves, S. Hartmann, P. Yu, F. Nimmerjahn, D. Voehringer. 2014.
Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine
secretion, PNAS, 111:169-177.
Hering, N.A., J.F. Richter, A. Fromm, A. Wieser, S. Hartmann, D. Günzel, R. Bücker, M.
Fromm, J.D. Schulzke, H. Troeger. 2014. TcpC protein from E. coli Nissle improves epithelial
barrier function involving PKCζ and ERK1/2 signalling in HT-29/B6 cells. Mucosal Immunol.,
7:369-378.

2013
Rausch, S., J. Held, A. Fischer, M. M. Heimesaat, A. A. Kühl, S. Bereswill, and S. Hartmann.
2013. Small intestinal nematode infection of mice is associated with increased enterobacterial
loads alongside the intestinal tract. PLoS ONE, 8: e74026.
Daniłowicz-Luebert, E., S. Steinfelder, A. Kühl, G. Drozdenko, R. Lucius, M. Worm, E.
Hamelmann, S. Hartmann. 2013. A nematode immunomodulator inhibits grass pollen-specific
allergic responses by controlling excessive Th2 inflammation. Int. J. Parasitol., 43:201-210.
Peine, M., S. Rausch, C. Helmstetter, A. Fröhlich, A. N. Hegazy, A. A. Kühl, C. G. Grevelding,
T. Höfer, S. Hartmann, and M. Loehning. 2013. Stable T-bet+GATA-3+ Th1/Th2 hybrid cells
arise in vivo, can develop directly from naïve precursors, and limit immunopathologic
inflammation. PLoS Biology, 11:e1001633.
Bednorz, C., S. Guenther, K. Oelgeschläger, B. Kinnemann, R. Pieper, S. Hartmann, K.
Tedin, T. Semmler, K. Neumann, P. Schierack, A. Bethe, L.H. Wieler. 2013. Feeding the
probiotic Enterococcus faecium strain NCIMB 10415 to piglets specifically reduces the number
of Escherichia coli pathotypes that adhere to the gut mucosa. Appl Environ Microbiol. 79:7896-
7904.
Bednorz, C., K. Oelgeschläger, B. Kinnemann, S. Hartmann, K. Neumann, R. Pieper, A.
Bethe, T. Semmler, K. Tedin, P. Schierack, L.H. Wieler, S. Guenther. 2013. The broader
context of antibiotic resistance: zinc feed supplementation of piglets increases the proportion
of multi-resistant Escherichia coli in vivo. Int J Med Microbiol. 303:396-403.
Steinfelder, S., Rausch, R. Lucius, S. Hartmann: „Nematode Allergens“ in „Parasitic
Nematodes: Molecular Biology, Biochemistry and Immunology. 2nd Edition. 2013. CABI
Publishing. Edited by M. Kennedy and B. Harnett.

2012
Hepworth, M.R., E. Daniłowicz-Luebert, S. Rausch, M. Metz, C. Klotz, M. Maurer, S.
Hartmann. 2012. A critical role for mast cells in the orchestration of type 2 immunity to
gastrointestinal helminths. PNAS, 106:6644-6649.
Hepworth M.R., M. Maurer, S. Hartmann. 2012. Regulation of type 2 immunity to helminths by
mast cells. Gut Microbes, 3: 476-481.
Hepworth, M.R., S. Hartmann. 2012. Worming our way closer to the clinic. IJPDR, 187-190.
Whelan R.A., S. Hartmann, S. Rausch. 2012. Nematode modulation of inflammatory bowel
disesase. Protoplasma, 249:871-886.
Stange, J., M. Hepworth, S. Rausch, L. Zajic, A.J. Kühl, C. Uyttenhove, J.C. Renauld, S.
Hartmann, R. Lucius. 2012. IL-22 mediates host defense against an intestinal intracellular
parasite in the absence of IFN-γ at the cost of Th17-driven immunopathology. J Immunol.,
188:2410-2418.
Greiff, V., H. Redestig, J. Lück, N. Bruni, A. Valai, S. Hartmann, S. Rausch, J. Schuchhardt
and M. Or-Guil. 2012. A minimal model of peptide binding predicts ensemble properties of
serum antibodies. BMC Genomics, 13:79.

2011
Klotz, C., T. Ziegler, A.S. Figueiredo, S. Rausch, M. Hepworth, C. Sers, R. Lang, P.
Hammerstein, R. Lucius, S. Hartmann. 2011. A helminth immunomodulator exploits host
signaling events to regulate cytokine production in macrophages. PLoS Pathogens,
7:e1001248.
Danilowicz-Luebert, E., N.L. O’Regan, S. Steinfelder, S. Hartmann. 2011. Modulation of
specific and allergen-related immune responses by helminths. J Biomed. Biotechnol.,
2011:821578.
Klotz, C., T. Ziegler, E. Danilowicz, S. Hartmann: „Cystatins of parasitic organisms“ in
„Cysteine Proteases of Pathogenic Organisms“. Landes Bioscience and Springer Science.
Edited by M. W. Robinson and J. P. Dalton. 2011.

2010
Rausch, S., J. Held, J, Stange, M. Lendner, M. Hepworth, C. Klotz, R. Lucius, T. Pogonka, S.
Hartmann. 2010. A Matter of Timing: Impact of intestinal nematode infection on concurrent
enteric protozoan infection. Eur. J. Immunol., 40:2804-2815.
Hepworth, M., E. Hamelmann, R. Lucius, S. Hartmann. 2010. Looking into the future of
Trichuris suis therapy. J. Allergy Clin. Immunol., 124:767-768.
Sereda, M., S. Hartmann, D. Büttner, R. Volkmer, M. Hövestädt, N. Brattig, R. Lucius. 2010.
Characterization of filarial tropomyosin with an invertebrate specific monoclonal antibody. Acta
Tropica, 116:61-67.

2009
Rausch, S., J. Huehn, C. Loddenkemper, M. Hepworth, C. Klotz, T. Sparwasser, A. Hamann,
R. Lucius, S. Hartmann. 2009. Establishment of nematode infection despite increased Th2
responses and immunopathology after selective depletion of Foxp3+ cells. Eur. J. Immunol.,
39:3066-3077.
Hartmann, S., C. Schnoeller, A. Dahten, A. Avagyan, S. Rausch, M. Lendner, C. Bocian, S.
Pillai, R. Lucius, M. Worm, E. Hamelmann. 2009. Gastrointestinal nematode infection
interferes with experimental allergic airway inflammation but not atopic dermatitis. Clinical &
Experimental Allergy, 39:1585-1596.
Rzepecka, J., S. Rausch, C. Klotz, C. Schnöller, T. Kornprobst, J. Hagen, R. Ignatius, R.
Lucius, S. Hartmann. 2009. Calreticulin from the intestinal nematode Heligmosomoides
polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A. Molecular
Immunology, 46:1109-1119.
He, Y., A. MacDonald, Y. Yu, L. Cao, J. Li, R. Parhar, S. Heck, S. Hartmann, D. Golenbock,
S. Jiang, S. Lustigman. 2009. Av-ASP-1, a Th1-biased protein adjuvant derived from the
helminth Onchocerca volvulus, bind primarily to antigen-presenting cells and induces
proinflammatory cytokines via the activation of toll-like receptors 2 and 4. J. Immunol, 182:
4005-4016.
Figueiredo, A. S., T. Höfer, C. Klotz, C. Sers, S. Hartmann, R. Lucius, P. Hammerstein. 2009.
Modelling and simulating IL-10 production and regulation by macrophages after stimulation
with an immunomodulator of parasitic nematodes. FEBS J., 276:3454-3469.

2008
Schnöller, C., S. Rausch, S. Pillai, A. Avagyan, B. Wittig, C. Loddenkemper, A. Hamann, E.
Hamelmann, R. Lucius, S. Hartmann. 2008. A helminth immunomodulator reduces allergic
and inflammatory responses by induction of IL-10-producing macrophages. J. Immunol., 180:
4265-4272.
Rausch, S., J. Huehn, D. Kirchhoff, J. Rzepecka, C. Schnöller, S. Pillai, C. Loddenkemper, A.
Scheffold, A. Hamann, R. Lucius, S. Hartmann. 2008. Interaction of effector and regulatory T
cells in a parasitic nematode infection. Infect. Immun., 76: 1908-1919.
Lendner M., R. Lucius, S. Hartmann. 2008. RNA interference in Heligmosomoides polygyrus:
new aspects; Mol. Biochem. Parasitology, 16: 21-31.
Sereda M.J., S. Hartmann, R. Lucius. 2008. Helminhs and allergy: the example of
tropomyosin. Trends Parasitol., 24: 272-278.
Dahten, A., C. Koch, D. Ernst, C. Schnöller, S. Hartmann, M. Worm. 2008. Systemic PPARg
ligation inhibits allergic immune response in the skin. J. Invest. Dermatol., 128: 2211-2218.

2007
Kirchhoff, D., M. Frentsch, P. Leclerk, D. Bumann, S. Rausch, S. Hartmann, A. Thiel, A.
Scheffold. 2007. Identification and isolation of murine antigen-reactive T cells according to
CD154 expression. Eur. J. Immunol., 37: 2370-2377.

2006
Hartmann, S., M. Sereda, A. Sollwedel, B. Kalinna, Lucius R. 2006. A nematode allergen
elicits protection against challenge infection under specific conditions. Vaccine, 24: 3581-3590.
Rzepecka, J., R. Lucius, M. Doligalska, S. Beck, S. Rausch, S. Hartmann. 2006. Studies on
screening for immunomodulatory proteins of the intestinal parasitic nematode
Heligmosomoides polygyrus. Parasite Immunology, 28: 463-472.
Rajakumar, S, W. Bleiss, S. Hartmann, P. Schierack, A. Marko, R. Lucius. 2006. Concomitant
immunity in a rodent model of filariasis, the infection of Meriones unguiculatus with
Acanthocheilonema viteae. Parasitology, 92: 41-45.

2005
Pillai, S., B. Kalinna, E. Liebau, S. Hartmann, F. Theuring, R. Lucius. 2005. Studies on
Acanthocheilonema viteae cystatin: Genomic organization, promoter studies and expression in
C. elegans. Filaria Journal, 4: 9-19.

2003
Hartmann, S., R. Lucius. 2003. Modulation of host immune responses by nematode cystatins.
Int. J. Parasitol., 33: 1291-1302.
Schierack, P., R. Lucius, B. Sonnenburg, K. Schilling, S. Hartmann. 2003. Parasite specific
immunomodulatory functions of filarial cystatin. Infect. Immun., 71: 2422-2429.
Hartmann, S., A. Sollwedel, A. Hoffmann, B. Sonnenburg, R. Lucius. 2003. Characterization
of IgE responses in a rodent model of filariasis and the allergenic potential of filarial antigens
using an in vitro assay. Parasite Immunol., 25: 9-16.

2002
Hartmann, S., A. Schönemeyer, B. Sonnenburg, B. Vray, R. Lucius. 2002. Cystatins of filarial
nematodes up-regulate the nitric oxide production of interferon-g-activated murine
macrophages. Parasite Immunol., 24: 253-262.
Drabner, B., U. Reineke, J. Schneider-Mergener, R. E. Humphreys, S. Hartmann, R. Lucius.
2002. Identification of T helper cell-recognized epitopes in the chitinase of the filarial nematode
Onchocerca volvulus. Vaccine, 20: 3685-3694.
Vray, B., S. Hartmann, J. Hoebeke. 2002. Immunomodulatory properties of cystatins. Cell.
Mol. Life Sci., 59: 1503-1512.
Bleiss, W., U. Oberlander, S. Hartmann, R. Adam, A. Marko, A. Schonemeyer, R. Lucius.
2002. Protective immunity induced by irradiated third-stage larvae of the filaria
Acanthocheilonema viteae is directed against challenge third-stage larvae before molting. J.
Parasitol., 88: 264-270.

2001
Schönemeyer, A., R. Lucius, B. Sonnenburg, N. Brattig, R. Sabat, K. Schilling, J. Bradley, S.
Hartmann. 2001. Modulation of human T cell responses and macrophage functions by
onchocystatin, a secreted protein of the filarial nematode Onchocerca volvulus . J. Immunol.,
167: 3207-3215.

1997
Hartmann, S., B. Kyewski, B. Sonnenburg, R. Lucius. Eur. J. Immunol. 1997. A filarial
cysteine protease inhibitor down-regulates T cell proliferation and enhances IL-10 production.
Eur. J. Immunol., 27: 2253-2260.
Hartmann, S., R. Adam, T. Marti, Ch. Kirsten, S. Seidinger, R. Lucius. 1997. A 41-kDa antigen
of the rodent filaria Acanthocheilonema viteae with homologies to tropomyoin induces hostprotective
immune responses. Parasitol. Res., 83: 390-393.

1996
Verdot, L., G. Lalmanach, V. Vercruysse, S. Hartmann, R. Lucius, J. Hoebeke, F. Gauthier, B.
Vray. 1996. Cystatins up-regulate nitrite oxide release from interferon-gamm activated mouse
peritoneal macrophages. J. Biol. Chem., 271: 28077-28081.